Star Trek: Voyager takes place in the 2370s, in the Milky Way Galaxy, and follows the adventures of the Starfleet vessel U.S.S. Voyager NCC-74656, commanded by Captain Kathryn Janeway. Janeway is a tough captain, not afraid to take chances, and is highly intelligent, thoughtful, dedicated, and diplomatic.

 U.S.S. Voyager was one of the earliest Intrepid-class starships constructed and featured a number of technological innovations that had become available in the 2370s including bio-neural circuitry, variable geometry warp nacelles, and an Emergency Medical Holographic program.